Trade sanctions are an increasingly common weapon. Against Russia, China, Venezuela, Iran, Turkey. In top of trade disruptions such as Brexit. And all of them constitute great opportunities, disguised as risks, provided the use of the proper methodology. Using Brexit as an example, this book provides such a simple and highly effective tool to be equally used by companies, industrial associations or even countries. The output, is always the same: a shortlist of the best business niches and the name of the main clients to focus on, among 140.400 alternatives (5.400 niches in each country multiplied by 26 EU countries). And where each opportunity niche represents hundreds of times a company's present turnover. Ravo BV in Netherlands, FlexNgate in Spain, Astellas in Ireland or BASF in Belgium are among the examples. This book is thus useful to whom wants to profit from Brexit or take advantage of the next trade war. Recalling Machiavelli recommendation of: never to waste the opportunities created by a good crisis